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Aim – to study characteristics of autonomic heart regulation in patients with coronary heart disease (CHD) associated with hemodynamically significant and insignificant coronary stenoses. Methods – 143 patients with CHD aged 49±8 years were enrolled in the study. 88 patients had at list one coronary artery stenosis of more then 50%. 55 CHD patients had no such stenoses. Rhythmograms at rest and during veloergometric test (VET) with exercise of 25 and 50 Wt were registered during 6 minutes at each stage. The first 3 minutes were registered at spontaneous breathing. The last 3 minutes were registered at controlled breathing with 10 seconds period. Frequency power of heart rate variability (HRV) spectrum in low-frequency (LF) and in high-frequency (HF) ranges was estimated. It was assumed that the power of LF-range in a parametric spectrum determined by the power of 0.1 Hz oscillations in HRV. Results – the dynamic of power of LF- range of HRV spectrum during the stages of VET at spontaneous breathing did not differ reliably in CHD patients with coronary stenoses of more then 50% and without such stenoses. Reliably higher increase of LF-range power under switching from the spontaneous to the controlled breathing was revealed at rest and at exercise of 25 Wt in CHD patients with coronary stenosis of less then 50%. The dynamic of power of HF-range of HRV spectrum during VET repeated the changes in LF-range. Any reliable intergroup differences were not revealed. Conclusions – the evidence of autonomic dysfunction is associated with hemodynamically significant coronary stenoses.
Kiselev AR, Posnenkova OM. Dynamic evaluation of heart rate variability spectrum in coronary heart disease patients with hemodynamically significant coronary stenoses. Bulletin of Medical Internet Conferences 2011; 1(1): 27-30.