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A model of human cardiovascular system is proposed which describes the main heart rhythm, the regulation of heart function and blood vessels by the autonomic nervous system, baroreflex, and the formation of arterial blood pressure. The model takes into account the impact of respiration on these processes. It is shown that taking into account nonlinearity and introducing the autonomous loop of mean arterial blood pressure in the form of self-oscillating time-delay system allow to obtain the model signals whose statistical and spectral characteristics are qualitatively and quantitatively similar to those for experimental signals. The proposed model demonstrates the phenomenon of synchronization of mean arterial pressure regulatory system by the signal of respiration with the basic period close to 10 seconds, which is observed in the physiological experiments.
Karavaev AS, Ishbulatov YM, Ponomarenko VI, Prokhorov MD, Gridnev VI, Bezruchko BP, Kiselev AR. Model of human cardiovascular system with a loop of autonomic regulation of the mean arterial pressure. J Am Soc Hypertens 2016; 10(3): 235-243.