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It is considered that 0.1 Hz-oscillations in heart rate variability (HRV) are determined by features of the central part of system of autonomic regulation. Aim – to study an influence of the degree of coronary stenosis on 0.1 Hz oscillations in heart rate variability in patients with coronary heart disease (CHD). Methods – 92 patients with CHD associated with stenosis of more then 50% in one or two coronary arteries aged 51±5 years were enrolled in the study. Subgroup of patients with coronary stenosis of more then 75% was singled out (n=78). Rhythmograms at rest and during veloergometric test (VET) with exercise of 25 and 50 Wt were registered during 6 minutes at each stage. The first 3 minutes were registered at spontaneous breathing. The last 3 minutes were registered at controlled breathing with 10 seconds period. Frequency power of HRV spectrum in low-frequency (LF) and in high-frequency (HF) ranges was estimated. It was assumed that the power of LF-range in a parametric spectrum determined by the power of 0.1 Hz oscillations in HRV. Results – the subgroup of patients with CHD associated with coronary stenosis of more then 75% did not differ reliably from the hole group of patients with coronary stenosis of more then 50% neither by absolute values nor by the dynamic of power of LF and HF ranges in HRV spectrum during VET. Conclusions – the degree of autonomic dysfunction associated with hemodynamically significant coronary stenosis does not depend on the further severity of the stenosis.
Kiselev AR, Gridnev VI, Posnenkova OM Autonomic dysfunction in coronary heart disease patients with hemodynamically significant coronary stenoses of varying degrees. Bulletin of Medical Internet Conferences 2011; 1(5): 30-33.