Method for diagnostics of synchronization of 0.1 Hz rhythms of cardiovascular system autonomic regulation in real time

It is known that synchronization of slow (~0.1 Hz) oscillations in heart rate and distal blood flow have a certain value for clinical cardiology. Previously we studied these oscillations by simultaneous recordings of electrocardiograms (ECG) and photoplethysmogram (PPG). A novel method is proposed for detecting in real time the phase synchronization of slow oscillations in heart rate and distal blood flow from the single signal of PPG. We verified our method by applying it to experimental data (10-minute simultaneous recording of ECG and PPG at rest) from 12 healthy subjects aged 18-34 years. The average error of assess the phase synchronization of 0.1 Hz oscillations was 6.9±3.6%.